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Design of nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleicacid drugs: learning from virus

Vaibhav Mundra, Ram I. Mahato

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 387-404 doi: 10.1007/s11705-014-1457-3

Abstract: many challenges in developing efficient and target specific delivery systems of small molecule and nucleicacid drugs.

Keywords： nanocarrier     cellular uptake     endosomal release     nucleic acid drug    

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Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom

Wen Zhang,Jack W. Szostak,Zhen Huang

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 196-202 doi: 10.1007/s11705-016-1565-3

Abstract: X-ray crystallography is a powerful strategy for 3-D structure determination of macromolecules, such as nucleicacids and protein-nucleic acid complexes.Recently we have successfully developed synthesis and strategy of selenium-derivatized nucleic acids(SeNA) for nucleic acid crystallography.

Keywords： selenium     DNA     RNA     nucleic acid     crystallization    

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Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Ulrich L?CHELT, Ernst WAGNER

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 3,   Pages 275-286 doi: 10.1007/s11705-011-1203-z

Abstract: In the case of nucleic acid therapy, non-viral carriers face several biological barriers during the deliveryengineering and conjugation of multifunctional polymeric structures for the utilization as “tailor-made” nucleicacid carriers.

Keywords： conjugate     DNA     gene transfer     polymer     RNA     targeting    

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Validation of polarizable force field parameters for nucleic acids by inter-molecular interactions

Liaoran Cao,Hong Ren,Jing Miao,Wei Guo,Yan Li,Guohui Li

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 203-212 doi: 10.1007/s11705-016-1572-4

Abstract: Modeling structural and thermodynamic properties of nucleic acids has long been a challenge in the developmenthave been proved to be reliable to model small molecules, polypeptides and proteins, but their use on nucleicIn this article, the interactions between nucleic acids and a small molecule or ion were modeled by AMOEBAbio09

Keywords： nucleic acid     polarizable force field     AMOEBA    

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Nucleic acid-based diagnostics for infectious diseases in public health affairs

Albert Cheung-Hoi Yu, Greg Vatcher, Xin Yue, Yan Dong, Mao Hua Li, Patrick H. K. Tam, Parker Y.L. Tsang, April K.Y. Wong, Michael H.K. Hui, Bin Yang, Hao Tang, Lok-Ting Lau

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 173-186 doi: 10.1007/s11684-012-0195-5

Abstract: Nucleic acid-based diagnostics, detecting pathogens through the identification of their genomic sequencesHere we review some of the most popular nucleic acid-based diagnostics and focus on their adaptabilityWe also compare and contrast the characteristics of different types of nucleic acid-based diagnostics

Keywords： nucleic acid-based diagnostics     infectious disease     PCR     NASBA     LAMP     microarray     LOAC     public health affairs    

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Development Trends and Suggestions of Nucleic Acid Vaccines

Li Aihua, Yang Xuemei, Sun Yinan, Yuan Yakun, Yang Juntao

Strategic Study of CAE 2021, Volume 23, Issue 4,   Pages 153-161 doi: 10.15302/J-SSCAE-2021.04.018

Abstract: This article first summarizes the R&D status of nucleic acid vaccines from the aspects of relatedacid vaccines.acid vaccines, and studies the possible technical and safety problems.Furthermore, we suggest that the key technologies of nucleic acid vaccines should be developed by improvingMoreover, the safety and efficacy of nucleic acid vaccines should be strictly monitored; stakeholders

Keywords： nucleic acid vaccine     deoxyribonucleic acid (DNA) vaccine     ribonucleic acid (RNA) vaccine     messenger    

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Flow cytometric assessment of the effects of chlorine, chloramine, and UV on bacteria by using nucleicacid stains and 5-cyano-2,3-ditolyltetrazolium chloride

Xuebiao Nie, Wenjun Liu, Mo Chen, Minmin Liu, Lu Ao

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 6, doi: 10.1007/s11783-016-0884-4

Abstract: Flow cytometry based on nucleic acid stains and CTC was established and optimized.Chlorine demonstrated stronger and faster destructive effects on cytomembrane than chloramine, and nucleic

Keywords： Flow cytometry     Escherichia coli     Staphylococcusaureus     UV     CTC     SYTO 9    

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Progress in terahertz nondestructive testing: A review

Shuncong ZHONG

Frontiers of Mechanical Engineering 2019, Volume 14, Issue 3,   Pages 273-281 doi: 10.1007/s11465-018-0495-9

Abstract: Recently, THz nondestructive testing (NDT) technology has become an interesting topic.

Keywords： terahertz pulsed imaging (TPI)     nondestructive testing (NDT)     composite material     thermal barrier coating    

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Sonic General Non-destructive Testing Technique

Chen Jimao

Strategic Study of CAE 2000, Volume 2, Issue 4,   Pages 64-69

Abstract:

This paper describes new general multi-mode non-destructive testing (NDT) of composite materials andThis technique which is based on sonic and ultrasonic testing performs five different modes of testing

Keywords： sonic general testing     general non-destructive testing (NDT)     non-destructive testing of composite materials     mechanical impedance analysis (MIA)     vibration analysis (VA)     resonance testing    

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Novel sensing techniques for full-scale testing of civil structures

Kaoshan DAI, Zhenhua HUANG

Frontiers of Structural and Civil Engineering 2012, Volume 6, Issue 3,   Pages 240-256 doi: 10.1007/s11709-012-0172-8

Abstract: Performing full-scale structural testing is an important methodology for researchers and engineers inFull scale testing helps the researchers understand civil infrastructures’ loading scenarios, behaviorsTo conduct a full-scale structural testing, sensors are used for data acquisitions.effective sensors, this study reviewed and categorized new sensing techniques for full-scale structural testingThe researchers of this study categorized sensors used for civil-infrastructure testing into traditional

Keywords： sensing technique     full-scale testing     wireless sensor     remote sensing     LiDAR     laser vibrometer    

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Development Strategy of Microbial Safety Industry

Song Zhongjian, Li Man, Hu Liangbin, Wang Chunming, Lu Xi, Liu Kaihui, Zhang Lijia, Yu Yan, Wu Qingping

Strategic Study of CAE 2021, Volume 23, Issue 5,   Pages 79-85 doi: 10.15302/J-SSCAE-2021.05.010

Abstract:

Microbial safety is crucial for China’s social and economic development in the new era, and it is an important support for national food security, public health, and social stability. In this article, we analyze the development needs and current status of the microbial safety industry considering the policy environment in China. Subsequently, we clarify the domestic and global development patterns of the industry and summarize the challenges faced by the innovation and application of pathogenic microorganism detection and control technologies in China. Furthermore, we propose a development plan for building China’s microbial safety industry. To explore a high-quality development path, China should build innovation platforms and a large scientific database regarding microbial safety, enhance personnel development for this industry, encourage leading enterprises to develop according to standards and regulations, and strengthen major system innovation and engineering technology research in the microbial safety field.

Keywords： microbial safety     microbial detection     microbial diagnosis     microbial prevention and control     nucleicacid detection    

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Research Progress in Molecular Identification Technology for Microbial Resources

Zhang Yu, Ma Aijin, Gao Lifen, Peng Hai, Jia Yingmin, Sun Baoguo

Strategic Study of CAE 2021, Volume 23, Issue 5,   Pages 86-93 doi: 10.15302/J-SSCAE-2021.05.011

Abstract: application for microbial resources in China and abroad; these technologies include deoxyribonucleic acid(DNA) (G+C) mol% identification, nucleic acid hybridization, DNA fingerprinting, nucleic acid amplification

Keywords： microbial resources     molecular identification     nucleic acid amplification technique     gene chip technology    

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A High-Throughput, Multi-Index Isothermal Amplification Platform for Rapid Detection of 19 Types of Common Respiratory Viruses Including SARS-CoV-2 Article

Wanli Xing, Yingying Liu, Huili Wang, Shanglin Li, Yongping Lin, Lei Chen, Yan Zhao, Shuang Chao, Xiaolan Huang, Shaolin Ge, Tao Deng, Tian Zhao, Baolian Li, Hanbo Wang, Lei Wang, Yunpeng Song, Ronghua Jin, Jianxing He, Xiuying Zhao, Peng Liu, Weimin Li, Jing Cheng

Engineering 2020, Volume 6, Issue 10,   Pages 1130-1140 doi: 10.1016/j.eng.2020.07.015

Abstract: Here, we present a high-throughput, multi-index nucleic acid isothermal amplification analyzer (RTisochip

Keywords： Coronavirus disease 2019     Severe acute respiratory syndrome coronavirus 2     Microfluidics     Nucleic acidtesting     Isothermal    

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Permeability testing of drilling core sample from pavement

WANG Suda, TANG Zhengguang, NING Xiaojun, WU Peiguan, XING Pingyi

Frontiers of Structural and Civil Engineering 2008, Volume 2, Issue 4,   Pages 391-394 doi: 10.1007/s11709-008-0045-3

Abstract: equipment is used to measure the permeability coefficient of the pavement drilling core sample and relevant testingTesting drilling core samples from a certain highway of Yunnan province has been proven to be feasible

Keywords： province     material     feasible     permeability coefficient     equipment    

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Shaking table testing of hard layered soil-pile-structure interaction system

LI Peizhen, REN Hongmei, LU Xilin, SONG Heping, CHEN Yueqing

Frontiers of Structural and Civil Engineering 2007, Volume 1, Issue 3,   Pages 346-352 doi: 10.1007/s11709-007-0046-7

Abstract: Shaking table tests on a dynamic interaction system of hard layered soil, pile foundation and frame structure were carried out. The earthquake damage of the superstructure and foundation was reproduced. Based on these tests, several key issues about the seismic response of the dynamic soil-structure interaction (SSI) system were studied. The natural frequency of the system was less than that of the structure on rigid foundation if the SSI is not taken into account, while its damping ratio was larger than that of the structure. The mode shape of the system was different from that of the structure on the fixed base in that there were rocking and swinging at the foundation. Magnification or reduction of vibration transferred by soil was related to soil characteristic, excitation magnitude, and so on. Generally, sand magnifies vibration, while viscous powder soil dampens vibration. The components of the acceleration response at the top of the superstructure were based on the relative magnitude of the rocking stiffness, the swing stiffness of the foundation and the stiffness of the super-structure. The multi-direction excitations have little effect on the key issues of the horizontal SSI.

Keywords： super-structure     Generally     Magnification     frequency     different    

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Title Author Date Type Operation

Design of nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleicacid drugs: learning from virus

Vaibhav Mundra, Ram I. Mahato

Journal Article

Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom

Wen Zhang,Jack W. Szostak,Zhen Huang

Journal Article

Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Ulrich L?CHELT, Ernst WAGNER

Journal Article

Validation of polarizable force field parameters for nucleic acids by inter-molecular interactions

Liaoran Cao,Hong Ren,Jing Miao,Wei Guo,Yan Li,Guohui Li

Journal Article

Nucleic acid-based diagnostics for infectious diseases in public health affairs

Albert Cheung-Hoi Yu, Greg Vatcher, Xin Yue, Yan Dong, Mao Hua Li, Patrick H. K. Tam, Parker Y.L. Tsang, April K.Y. Wong, Michael H.K. Hui, Bin Yang, Hao Tang, Lok-Ting Lau

Journal Article

Development Trends and Suggestions of Nucleic Acid Vaccines

Li Aihua, Yang Xuemei, Sun Yinan, Yuan Yakun, Yang Juntao

Journal Article

Flow cytometric assessment of the effects of chlorine, chloramine, and UV on bacteria by using nucleicacid stains and 5-cyano-2,3-ditolyltetrazolium chloride

Xuebiao Nie, Wenjun Liu, Mo Chen, Minmin Liu, Lu Ao

Journal Article

Progress in terahertz nondestructive testing: A review

Shuncong ZHONG

Journal Article

Sonic General Non-destructive Testing Technique

Chen Jimao

Journal Article

Novel sensing techniques for full-scale testing of civil structures

Kaoshan DAI, Zhenhua HUANG

Journal Article

Development Strategy of Microbial Safety Industry

Song Zhongjian, Li Man, Hu Liangbin, Wang Chunming, Lu Xi, Liu Kaihui, Zhang Lijia, Yu Yan, Wu Qingping

Journal Article

Research Progress in Molecular Identification Technology for Microbial Resources

Zhang Yu, Ma Aijin, Gao Lifen, Peng Hai, Jia Yingmin, Sun Baoguo

Journal Article

A High-Throughput, Multi-Index Isothermal Amplification Platform for Rapid Detection of 19 Types of Common Respiratory Viruses Including SARS-CoV-2

Wanli Xing, Yingying Liu, Huili Wang, Shanglin Li, Yongping Lin, Lei Chen, Yan Zhao, Shuang Chao, Xiaolan Huang, Shaolin Ge, Tao Deng, Tian Zhao, Baolian Li, Hanbo Wang, Lei Wang, Yunpeng Song, Ronghua Jin, Jianxing He, Xiuying Zhao, Peng Liu, Weimin Li, Jing Cheng

Journal Article

Permeability testing of drilling core sample from pavement

WANG Suda, TANG Zhengguang, NING Xiaojun, WU Peiguan, XING Pingyi

Journal Article

Shaking table testing of hard layered soil-pile-structure interaction system

LI Peizhen, REN Hongmei, LU Xilin, SONG Heping, CHEN Yueqing

Journal Article